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Harnessing the Power of Berberine for Optimal Health

Harnessing the Power of Berberine for Optimal Health

Berberine, scientifically known as berberine hydrochloride, is a bioactive compound naturally found in plants such as goldenseal, barberry, and Oregon grape. Belonging to a group of alkaloids, berberine has a rich history of use in traditional Chinese and Ayurvedic medicine, attributed to its diverse array of potential health benefits.

Upon ingestion, berberine enters the bloodstream and interacts with various molecules within the cells, influencing multiple physiological processes within the body. Let’s explore some of the compelling benefits that berberine can offer:

Blood Sugar Regulation: Berberine effectively improves insulin sensitivity and helps maintain blood sugar levels that are within the normal range.*
Weight Loss: Berberine supports weight loss by enhancing fat metabolism and decreasing fat storage.*
Heart Health: Berberine exhibits potential in lowering cholesterol and triglyceride levels, thereby promoting a healthy cardiovascular system.*
Antimicrobial Properties: Berberine’s antimicrobial effects have been utilized traditionally to combat bacterial, viral, and fungal disruptions, including potential benefits in addressing harmful gut bacteria.*
Anti-inflammatory and Antioxidant Effects: Berberine possesses anti-inflammatory properties and acts as a potent antioxidant, aiding in reducing oxidative stress and inflammation associated with various chronic conditions.*

Berberine is a key natural ingredient in ZipBURN^™, a proprietary, cutting-edge supplement specifically designed to provide optimal weight management support.* ZipBURN contains a GLP-1 Synergizer blend—five herbal ingredients scientifically shown to naturally increase GLP-1 levels, and a new, patented bioactive postbiotic that fights abdominal fat and unhealthy visceral fat.*

ZipBURN^™ has been specifically designed to provide optimal weight management support and help you get fitter, healthier and happier!*

^{*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.}

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*Fifty overweight people (BMI 28-36) using a key ingredient in ZipSlim®, along with a lower calorie diet (1350 calories for women/1850 calories for men), lost 30 pounds in just 13 weeks, compared to just 10 pounds for those following the lower calorie diet alone.

F. Di Pierro, A.B. Menghi, A. Barreca, M. Lucarelli, and A. Calandrelli, “GreenSelect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial,” Alternative Medicine Review, vol. 14, no. 2, pp. 154-160, 2009.

Results may vary from person to person

When used as directed as part of your diet and exercise program.

Citations

Greenselect Phytosome for Borderline Metabolic Syndrome:
Belcaro G, Ledda A, Hu S, Cesarone MR, Feragalli B, Dugall M. Greenselect Phytosome for Borderline Metabolic Syndrome. Evid Based Complement Alternat Med. 2013;2013:869061. doi: 10.1155/2013/869061. Epub 2013 Nov 14.
Greenselect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial:
Di Pierro F, Menghi A, Barreca A, Lucarelli M, Calandrelli A. Greenselect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Altern Med Rev. 2009 Jun;14(2):154-60.
Prevalence of Optimal Metabolic Health in American Adults:
Joana Araújo, Jianwen Cai, June Stevens. Prevalence of Optimal Metabolic Health in American Adults: National Health and Nutrition Examination Survey 2009–2016. Metabolic Syndrome and Related DisordersVol. 17, No. 1
Prevalence of Overweight and Obesity Among Young People in Great Britain:
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Prevalence of Obesity and Severe Obesity Among Adults: United States, 2017–2018:
Craig M. Hales, M.D., Margaret D. Carroll, M.S.P.H., Cheryl D. Fryar, M.S.P.H., and Cynthia L. Ogden, Ph.D.NCHS Data Brief No. 360, February 2020.
Obesity Rate Nearly Triples in United States Over Last 50 Years:
https://usafacts.org/articles/obesity-rate-nearly-triples-united-states-over-last-50-years/
How America’s diet has changed over time:
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How Much Sugar Do You Eat? You May Be Surprised!
NH DHHS-DPHS-Health Promotion in Motion. August 2014.https://www.dhhs.nh.gov/dphs/nhp/documents/sugar.pdf
Chronic Stress, Cortisol Dysfunction, and Pain: A Psychoneuroendocrine Rationale for Stress Management in Pain Rehabilitation:
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Stress, overeating, and obesity: Insights from human studies and preclinical models:
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Stress eating and health. Findings from MIDUS, a national study of US adults:
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Excessive Sugar Consumption May Be a Difficult Habit to Break: A View From the Brain and Body:
Matthew S Tryon, Kimber L Stanhope, Elissa S Epel, Ashley E Mason, Rashida Brown, Valentina Medici , Peter J Havel , Kevin D Laugero. DOI: 10.1210/jc.2014-4353
Stress and body shape: Stress-induced cortisol secretion is consistently greater among women with central fat:
2. Epel ES, McEwen B, Seeman T, et al. Stress and body shape: Stress-induced cortisol secretion is consistently greater among women with central fat. Psychosom Med. 2000;62(5):623-632.
Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial:
Choudhary, D., Bhattacharyya, S., & Joshi, K. (2017). Journal of evidence-based complementary & alternative medicine, 22(1), 96-106. https://doi.org/10.1177%2F2156587216641830
Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?
Pournourmohammadi S, et. al. Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state? Int J Biochem Cell Biol. 2017 Jul;88:220-225. https://doi.org/10.1016/j.biocel.2017.01.012
Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5′-AMP-activated protein kinase:
Collins QF, et. al. Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5′-AMP-activated protein kinase. J Biol Chem. 2007 Oct 12;282(41):30143-9.https://doi.org/10.1074/jbc.m702390200
Relationship Between Rate and Extent of Catechin Absorption and Plasma Antioxidant Status:
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GreenSelect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial:
F. Di Pierro, A. B. Menghi, A. Barreca, M. Lucarelli, and A. Calandrelli, “GreenSelect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial,” Alternative Medicine Review, vol. 14, no. 2, pp. 154–160, 2009.
Green tea extract decreases starch digestion and absorption from a test meal in humans: a randomized, placebo-controlled crossover study:
Lochocka, K., Bajerska, J., Glapa, A. et al. Green tea extract decreases starch digestion and absorption from a test meal in humans: a randomized, placebo-controlled crossover study. Sci Rep5, 12015 (2015).https://doi.org/10.1038/srep12015
A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect of carbohydrate craving:
Docherty JP, Sack DA, Roffman M, Finch M, Komorowski JR. A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect of carbohydrate craving. J Psychiatr Pract. 2005; 11(5):302-314. (Pg. 310). DOI: 10.1097/00131746-200509000-00004
Effects of chromium picolinate supplementation on body composition:
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A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults:
Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). Indian journal of psychological medicine, 34(3), 255.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/
Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions:
Choudhary, D., Bhattacharyya, S., & Bose, S. (2017). Journal of Dietary Supplements, 1-14. Chicago. DOI: 10.1080/19390211.2017.1284970
Examining the effect of Withania somnifera supplementation on muscle strength and recovery:
Wankhede, S., Langade, D., Joshi, K., Sinha, S. R., & Bhattacharyya, S. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. (2015). Journal of the International Society of Sports Nutrition, 12(1), 43. DOI: 10.1186/s12970-015-0104-9
Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults:
Choudhary, B., Shetty, A., & Langade, D. G. Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults (2015). Ayu, 36(1), 63.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687242/
The Age When You Gain the Most Weight:
https://www.washingtonpost.com/news/wonk/wp/2016/01/29/the-age-when-you-gain-the-most-weight
Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety:
Langade D, Kanchi S, Salve J, et al. (September 28, 2019) Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study. Cureus 11(9): e5797. doi: 10.7759/cureus.5797
Increment in Dietary Potassium Predicts Weight Loss in the Treatment of the Metabolic Syndrome:
Tal, B.; Sack, J.; Yaron, M.; Shefer, G.; Buch, A.; Ben Haim, L.; Marcus, Y.; Shenkerman, G.; Sofer, Y.; Shefer, L.; Margaliot, M.; Stern, N. Increment in Dietary Potassium Predicts Weight Loss in the Treatment of the Metabolic Syndrome. Nutrients 2019, 11, 1256. DOI: 10.3390/nu11061256

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.