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The Gut-Brain Link: Your Mood’s Hidden Driver

July 2, 2025 No Comments

Did you know your gut and brain are in constant communication? This gut-brain connection influences your mood, energy, focus, and overall mental clarity. When your gut is out of balance, it can lead to brain fog, stress, and low mood—but with the right foods, habits, and supplements, you can support both gut health and a happier mind.

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*Fifty overweight people (BMI 28-36) using a key ingredient in ZipSlim®, along with a lower calorie diet (1350 calories for women/1850 calories for men), lost 30 pounds in just 13 weeks, compared to just 10 pounds for those following the lower calorie diet alone.

F. Di Pierro, A.B. Menghi, A. Barreca, M. Lucarelli, and A. Calandrelli, “GreenSelect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial,” Alternative Medicine Review, vol. 14, no. 2, pp. 154-160, 2009.

Results may vary from person to person

When used as directed as part of your diet and exercise program.

  • Greenselect Phytosome for Borderline Metabolic Syndrome:
    Belcaro G, Ledda A, Hu S, Cesarone MR, Feragalli B, Dugall M. Greenselect Phytosome for Borderline Metabolic Syndrome. Evid Based Complement Alternat Med. 2013;2013:869061. doi: 10.1155/2013/869061. Epub 2013 Nov 14.
  • Greenselect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial:
    Di Pierro F, Menghi A, Barreca A, Lucarelli M, Calandrelli A. Greenselect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Altern Med Rev. 2009 Jun;14(2):154-60.
  • Prevalence of Optimal Metabolic Health in American Adults:
    Joana Araújo, Jianwen Cai, June Stevens. Prevalence of Optimal Metabolic Health in American Adults: National Health and Nutrition Examination Survey 2009–2016. Metabolic Syndrome and Related DisordersVol. 17, No. 1
  • Prevalence of Overweight and Obesity Among Young People in Great Britain:
    Susan A Jebb  1 , Kirsten L Rennie, Tim J Cole. Prevalence of Overweight and Obesity Among Young People in Great Britain: Public Health Nutr. 2004 May;7(3):461-5. doi: 10.1079/PHN2003539. 
  • Prevalence of Obesity and Severe Obesity Among Adults: United States, 2017–2018:
    Craig M. Hales, M.D., Margaret D. Carroll, M.S.P.H., Cheryl D. Fryar, M.S.P.H., and Cynthia L. Ogden, Ph.D.NCHS Data Brief No. 360, February 2020. 
  • Obesity Rate Nearly Triples in United States Over Last 50 Years:
    https://usafacts.org/articles/obesity-rate-nearly-triples-united-states-over-last-50-years/ 
  • How America’s diet has changed over time:
    DeSilver, D. (2016, December 13). How America’s diet has changed over time. Retrieved fromhttp://www.pewresearch.org/fact-tank/2016/12/13/whats-on-your-table-how-americas-diet-has-changed-over-the-decades/
  • How Much Sugar Do You Eat? You May Be Surprised!
    NH DHHS-DPHS-Health Promotion in Motion. August 2014.https://www.dhhs.nh.gov/dphs/nhp/documents/sugar.pdf
  • Chronic Stress, Cortisol Dysfunction, and Pain: A Psychoneuroendocrine Rationale for Stress Management in Pain Rehabilitation:
    Kara E. Hannibal, Mark D. Bishop. Phys Ther. 2014 Dec; 94(12): 1816–1825.
  • Stress, overeating, and obesity: Insights from human studies and preclinical models:
    Maria Razzolia, Carolyn Pearson, ScottCrow, Alessandro Bartolomuccia.https://doi.org/10.1016/j.neubiorev.2017.01.026 
  • Stress eating and health. Findings from MIDUS, a national study of US adults:
    Tsenkova, V., Boylan, J. M., & Ryff, C. (2013). Stress eating and health. Findings from MIDUS, a national study of US adults. Appetite, 69, 151-155. Doi: 10.1016/j.appet.2013.05.020
  • Excessive Sugar Consumption May Be a Difficult Habit to Break: A View From the Brain and Body:
    Matthew S Tryon, Kimber L Stanhope, Elissa S Epel, Ashley E Mason, Rashida Brown, Valentina Medici , Peter J Havel , Kevin D Laugero. DOI: 10.1210/jc.2014-4353
  • Stress and body shape: Stress-induced cortisol secretion is consistently greater among women with central fat:
    2. Epel ES, McEwen B, Seeman T, et al. Stress and body shape: Stress-induced cortisol secretion is consistently greater among women with central fat. Psychosom Med. 2000;62(5):623-632.
  • Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial:
    Choudhary, D., Bhattacharyya, S., & Joshi, K. (2017). Journal of evidence-based complementary & alternative medicine, 22(1), 96-106. https://doi.org/10.1177%2F2156587216641830 
  • Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?
    Pournourmohammadi S, et. al. Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state? Int J Biochem Cell Biol. 2017 Jul;88:220-225. https://doi.org/10.1016/j.biocel.2017.01.012 
  • Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5′-AMP-activated protein kinase:
    Collins QF, et. al. Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5′-AMP-activated protein kinase. J Biol Chem. 2007 Oct 12;282(41):30143-9.https://doi.org/10.1074/jbc.m702390200 
  • Relationship Between Rate and Extent of Catechin Absorption and Plasma Antioxidant Status:
    Pietta P., Simonetti P., Gardana C., Brusamolino A., Morazzoni P., Bombardelli E. Biochem Mol Biol Int. 1998 Dec; 46(5):895-903. https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/15216549800204442 
  • GreenSelect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial:
    F. Di Pierro, A. B. Menghi, A. Barreca, M. Lucarelli, and A. Calandrelli, “GreenSelect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial,” Alternative Medicine Review, vol. 14, no. 2, pp. 154–160, 2009.
  • Green tea extract decreases starch digestion and absorption from a test meal in humans: a randomized, placebo-controlled crossover study:
    Lochocka, K., Bajerska, J., Glapa, A. et al. Green tea extract decreases starch digestion and absorption from a test meal in humans: a randomized, placebo-controlled crossover study. Sci Rep5, 12015 (2015).https://doi.org/10.1038/srep12015
  • A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect of carbohydrate craving:
    Docherty JP, Sack DA, Roffman M, Finch M, Komorowski JR. A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect of carbohydrate craving. J Psychiatr Pract. 2005; 11(5):302-314. (Pg. 310). DOI: 10.1097/00131746-200509000-00004
  • Effects of chromium picolinate supplementation on body composition:
    Kaats,GR, Blum K, Fisher JA, Adelman JA. Effects of chromium picolinate supplementation on body composition: a randomized, double-masked, placebo-controlled study. Current Therapeutic Research. 1996;57(10):747-756.. https://doi.org/10.1016/S0011-393X(98)85040-6 
  • A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults:
    Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). Indian journal of psychological medicine, 34(3), 255.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/ 
  • Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions:
    Choudhary, D., Bhattacharyya, S., & Bose, S. (2017). Journal of Dietary Supplements, 1-14. Chicago.  DOI: 10.1080/19390211.2017.1284970
  • Examining the effect of Withania somnifera supplementation on muscle strength and recovery:
    Wankhede, S., Langade, D., Joshi, K., Sinha, S. R., & Bhattacharyya, S. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. (2015). Journal of the International Society of Sports Nutrition, 12(1), 43. DOI: 10.1186/s12970-015-0104-9
  • Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults:
    Choudhary, B., Shetty, A., & Langade, D. G. Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults (2015). Ayu, 36(1), 63.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687242/ 
  • The Age When You Gain the Most Weight:
    https://www.washingtonpost.com/news/wonk/wp/2016/01/29/the-age-when-you-gain-the-most-weight
  • Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety:
    Langade D, Kanchi S, Salve J, et al. (September 28, 2019) Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study. Cureus 11(9): e5797. doi: 10.7759/cureus.5797
  • Increment in Dietary Potassium Predicts Weight Loss in the Treatment of the Metabolic Syndrome:
    Tal, B.; Sack, J.; Yaron, M.; Shefer, G.; Buch, A.; Ben Haim, L.; Marcus, Y.; Shenkerman, G.; Sofer, Y.; Shefer, L.; Margaliot, M.; Stern, N. Increment in Dietary Potassium Predicts Weight Loss in the Treatment of the Metabolic Syndrome. Nutrients 2019, 11, 1256. DOI: 10.3390/nu11061256

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.